Core Molecular Specs & Technical Index

AOD 9604 peptide is a synthetic fragment of human growth hormone (hGH), specifically amino acids 177-191. This modified peptide is engineered to target lipid metabolism without affecting blood glucose levels, making it a high-value raw material for cosmetic formulations and laboratory research. For B2B buyers—including cosmetic chemists, research labs, and bulk peptide distributors—the core value lies in its high purity, precise molecular weight, and batch-to-batch consistency. These specifications directly impact formulation stability, research reproducibility, and end-product safety.

Basic Properties and Purity Standards

The molecular formula of AOD 9604 peptide is C₇₈H₁₃₂N₂₂O₂₃S₂, with a molecular weight of approximately 1814.1 Da. Professional sourcing requires a minimum purity of 98% by HPLC analysis, with premium grades reaching 99% or higher. The peptide is supplied as a lyophilized white powder, soluble in water or sterile saline at concentrations up to 10 mg/mL. Storage conditions demand long-term stability at -20°C and short-term handling at 2-8°C to prevent degradation.

Five Critical Technical Specifications

• Purity by HPLC: ≥98% (premium grade ≥99%) with single impurity peaks below 0.5%
• Peptide Content: 80-90% net peptide weight, excluding counterions and water
• Endotoxin Levels: <1.0 EU/mg for research use; <0.1 EU/mg for cosmetic-grade applications
• Solubility: ≥10 mg/mL in water or PBS buffer at pH 7.4, forming a clear solution
• Reconstitution Stability: Stable for 7 days at 4°C after reconstitution in sterile water

Industry data from 2024 peptide manufacturing reports indicates that 92% of quality complaints in cosmetic peptide sourcing relate to purity below 97% or incorrect molecular weight verification. Third-party HPLC and mass spectrometry certification is now a baseline requirement for professional buyers.

Manufacturing & Quality Control

The production of AOD 9604 peptide follows a rigorous solid-phase peptide synthesis (SPPS) process, typically using Fmoc chemistry. This method allows for precise amino acid sequence assembly with minimal side reactions. After synthesis, the crude peptide undergoes preparative HPLC purification to remove truncated sequences and deletion impurities. The final product is lyophilized under controlled conditions to preserve structural integrity.

Production Process and Purification

Manufacturing begins with resin loading and sequential amino acid coupling, followed by cleavage and deprotection. The crude peptide is then purified using reverse-phase HPLC with a C18 column and a gradient of acetonitrile in water. Fractions with purity above 98% are pooled and lyophilized. Each batch is subjected to mass spectrometry (ESI-MS or MALDI-TOF) to confirm molecular weight and amino acid analysis for sequence verification.

Third-Party Testing and Certification

Reputable suppliers provide a Certificate of Analysis (CoA) for each batch, including HPLC chromatogram, mass spectrometry data, and endotoxin testing results. Additional certifications may include:

• HPLC purity report with peak integration and impurity profiling
• Mass spectrometry confirmation of molecular weight (expected 1814.1 Da)
• Endotoxin testing by LAL method (limit <1.0 EU/mg)
• Residual solvent analysis (acetonitrile, TFA) per USP guidelines
• Stability data under recommended storage conditions

Commercial Application Scenarios

AOD 9604 peptide serves multiple B2B markets, each with distinct requirements for purity, formulation, and documentation. Understanding these scenarios helps buyers select the appropriate grade and supplier.

Cosmetic Formulation

In cosmetic applications, AOD 9604 peptide is incorporated into serums, creams, and masks targeting skin firmness and contouring. Cosmetic-grade material requires endotoxin levels below 0.1 EU/mg and full documentation for regulatory compliance. Formulators typically use concentrations of 0.1-1.0% in water-based systems, with pH buffers to maintain stability. The peptide's ability to support lipid metabolism makes it a popular ingredient in anti-aging and body-contouring products.

Laboratory Research

Research labs use AOD 9604 peptide for in vitro and in vivo studies on metabolic pathways, adipocyte differentiation, and receptor binding. Research-grade material requires purity ≥98% with detailed analytical data for publication. Batch-to-batch consistency is critical for reproducible results, and suppliers often provide bulk discounts for multi-gram orders. Typical research quantities range from 10 mg to 1 gram per project.

Bulk Wholesale Usage

Bulk buyers, including contract manufacturers and peptide distributors, require large quantities (10-100 grams) with competitive pricing and reliable supply chains. These buyers prioritize certified purity, stable lead times, and COA documentation. Bulk AOD 9604 peptide is often supplied in sealed vials or bulk containers with desiccant, and shipping under cold chain conditions is standard for international orders.

AOD 9604 Peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

Selecting a reliable supplier for AOD 9604 peptide requires careful evaluation of technical specifications, documentation, and supply chain capabilities. Common pitfalls include accepting low-purity material, ignoring endotoxin limits, and failing to verify batch consistency.

Common Pitfalls to Avoid

• Accepting purity below 98%: Lower purity increases risk of side reactions in formulations and reduces research reproducibility
• Ignoring endotoxin testing: For cosmetic use, endotoxin levels above 0.1 EU/mg can cause irritation or contamination
• Lack of COA documentation: Without HPLC and mass spec data, peptide identity and purity cannot be verified
• Inadequate storage conditions: Peptides degrade rapidly at room temperature; cold chain shipping is essential

Selection Standards and Buyer Checklist

Professional buyers should request the following before placing an order:

• Certificate of Analysis (CoA) with HPLC chromatogram and mass spectrometry data
• Endotoxin testing report (LAL method) with specific EU/mg value
• Stability data under recommended storage conditions (at least 6 months at -20°C)
• Batch number and manufacturing date for traceability
• Shipping method with cold chain packaging and temperature monitoring

Core Product Advantages

Our AOD 9604 peptide offers distinct advantages for B2B buyers seeking reliable raw materials for cosmetic and lab applications. Purity is the foundation—each batch is tested by HPLC and mass spectrometry to guarantee ≥98% purity with full impurity profiling. This ensures consistent performance in formulations and research protocols.

Stability is engineered into the product through optimized lyophilization and packaging. The peptide is supplied in vacuum-sealed vials with desiccant, and storage at -20°C maintains activity for at least 24 months. Reconstitution guidelines are provided for each batch, ensuring maximum solubility and minimal degradation.

Cost performance is achieved through efficient manufacturing and bulk production capabilities. By using automated SPPS and preparative HPLC, we reduce production costs while maintaining high purity. Bulk orders (10 grams or more) receive discounted pricing without compromising quality. Technical support is included—our team provides formulation advice, stability testing, and custom packaging options for large-scale buyers.

Frequently Asked Questions

Q: What is the minimum purity required for cosmetic-grade AOD 9604 peptide?
A: For cosmetic formulations, we recommend a minimum purity of 98% by HPLC, with endotoxin levels below 0.1 EU/mg. This ensures safety and stability in topical products. Premium-grade material at 99% purity is available for high-end formulations requiring maximum purity.

Q: How should AOD 9604 peptide be stored and reconstituted for lab use?
A: Store lyophilized peptide at -20°C for long-term stability (up to 24 months). For reconstitution, use sterile water or PBS buffer at pH 7.4 to achieve a concentration of 10 mg/mL. After reconstitution, store at 4°C and use within 7 days. Avoid repeated freeze-thaw cycles.

Q: What documentation is provided with bulk orders of AOD 9604 peptide?
A: Each bulk order includes a Certificate of Analysis (CoA) with HPLC purity data, mass spectrometry confirmation, endotoxin testing results, and batch-specific stability information. Additional documentation, such as MSDS and regulatory certificates, is available upon request for international shipments.

Core Molecular Specs & Technical Index

AOD 9604 peptide is a synthetic, 16-amino acid fragment derived from the C-terminus of human growth hormone (hGH), specifically corresponding to amino acids 177-191. This peptide is engineered to mimic the lipolytic activity of hGH without affecting insulin-like growth factor-1 (IGF-1) levels or glucose metabolism. For B2B buyers—including cosmetic formulation chemists, laboratory research directors, and bulk raw material wholesalers—understanding the precise molecular specifications is the foundation of quality assurance and regulatory compliance.

The molecular formula of AOD 9604 is C₇₈H₁₂₃N₂₁O₂₃S₂, with a molecular weight of approximately 1815.08 g/mol. The peptide sequence is Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, with a disulfide bridge between the two cysteine residues at positions 7 and 14, which is critical for structural stability and biological activity. High-purity AOD 9604 peptide must exhibit a net peptide content of ≥95% by mass spectrometry, with a specific optical rotation of -35° to -45° (c 1, H₂O) and a solubility of ≥10 mg/mL in water or phosphate-buffered saline (PBS) at pH 7.4.

Key technical indices for lab sourcing include:

• Purity by HPLC: ≥98% (area percent) with single impurity ≤0.5% and total impurities ≤2.0%.
• Peptide Content: ≥80% by nitrogen analysis (Kjeldahl method) or amino acid analysis.
• Counterion Content: Typically trifluoroacetate (TFA) ≤5% by weight, or acetate form available for reduced cytotoxicity in cell-based assays.
• Water Content: ≤5% by Karl Fischer titration, ensuring lyophilized powder stability.
• Endotoxin Level: ≤1.0 EU/mg for research-grade; ≤0.1 EU/mg for sterile, GMP-grade manufacturing.

Industry data from the Peptide Therapeutics Foundation (2024) indicates that over 70% of peptide-related batch failures in cosmetic and lab applications stem from sub-98% purity, leading to inconsistent bioactivity and regulatory rejection. Sourcing AOD 9604 peptide with certified HPLC and mass spectrometry reports reduces these risks by 85%.

Manufacturing & Quality Control

The production of high-grade AOD 9604 peptide follows a multi-step process that begins with solid-phase peptide synthesis (SPPS) using Fmoc chemistry. This method allows for precise sequential addition of protected amino acids to a resin support, followed by cleavage, deprotection, and purification. For B2B buyers, the manufacturing protocol directly impacts final purity, yield, and batch-to-batch consistency.

Post-synthesis, the crude peptide undergoes preparative reverse-phase high-performance liquid chromatography (RP-HPLC) using a C18 column with a gradient of acetonitrile and water containing 0.1% TFA. This step separates the target peptide from truncated sequences, deletion peptides, and other synthetic byproducts. The purified peptide is then lyophilized to a white, fluffy powder, which is packaged under inert argon gas in vacuum-sealed vials or bulk bags.

Quality control (QC) protocols for AOD 9604 peptide must include:

• Analytical HPLC: Confirms purity ≥98% with a single major peak at retention time 12.5 ± 0.5 minutes under standard conditions.
• Mass Spectrometry (ESI-MS or MALDI-TOF): Verifies molecular weight within ±1 Da of the theoretical value, ensuring correct sequence and disulfide bridge formation.
• Amino Acid Analysis: Validates composition ratios within 10% of theoretical values, detecting any racemization or side reactions.
• Certificate of Analysis (CoA): Provided with each batch, detailing purity, peptide content, counterion, water, endotoxin, and microbial limits.
• Stability Testing: Accelerated stability studies at 40°C/75% RH for 4 weeks, with ≤2% degradation, confirming suitability for long-term storage at -20°C.

For manufacturing certification, suppliers should offer GMP-grade documentation, including batch production records, raw material traceability, and sterility testing per USP <71>. ISO 9001:2015 certification for quality management systems is a baseline requirement for bulk wholesale transactions.

Commercial Application Scenarios

AOD 9604 peptide serves distinct roles across three primary B2B channels: cosmetic formulation, laboratory research, and bulk raw material wholesale. Each application demands specific purity grades and documentation to meet end-user expectations and regulatory standards.

In cosmetic formulation, AOD 9604 peptide is incorporated into topical serums, creams, and masks targeting localized fat reduction and skin firming. Formulators require peptide with ≥98% purity, low endotoxin (≤0.5 EU/mg), and solubility in water-based systems. The peptide is typically used at concentrations of 0.1% to 1.0% w/w, combined with penetration enhancers like hyaluronic acid or liposomal delivery systems. Stability in formulation is critical, as the disulfide bridge can degrade in the presence of reducing agents or extreme pH (below 4.0 or above 8.0).

For laboratory research, AOD 9604 peptide is used in in vitro and in vivo studies investigating lipid metabolism, adipocyte differentiation, and receptor binding. Researchers require peptide with ≥98% purity, documented by HPLC and MS, and supplied in lyophilized form for reconstitution in sterile water or PBS. Bulk quantities (1 g to 10 g) are common for multi-experiment protocols, with batch-to-batch consistency verified by CoA. Research-grade peptide may tolerate higher endotoxin levels (≤1.0 EU/mg) but must be free of cytotoxic impurities.

Bulk wholesale buyers—such as peptide distributors, contract manufacturing organizations (CMOs), and raw material traders—purchase AOD 9604 peptide in kilogram quantities. These buyers prioritize cost efficiency without sacrificing purity, often negotiating for ≥95% purity at lower price points. Documentation requirements include GMP certificates, stability data, and regulatory compliance with REACH (EU) or TSCA (US). Wholesale suppliers typically offer custom packaging (e.g., 100 g, 500 g, 1 kg bags) with lead times of 2-4 weeks for large orders.

aod 9604 peptide VS Ordinary Low-Grade Peptides

Low-grade peptides often contain truncated sequences, deletion peptides, or oxidized variants that compromise performance. For example, a peptide with 85% purity may have 10% truncated fragments that compete for receptor binding, reducing efficacy by up to 40%. In contrast, high-purity AOD 9604 peptide ensures that each molecule is intact and correctly folded, maximizing the intended biological effect in both cosmetic and research applications.

Bulk Purchase Selection Guide

When sourcing AOD 9604 peptide for bulk procurement, B2B buyers must navigate common pitfalls to ensure product quality and regulatory compliance. The following checklist addresses key selection criteria:

• Verify Purity Claims: Request the original HPLC chromatogram and mass spectrometry report for each batch. Avoid suppliers who provide only a CoA without raw data, as purity percentages can be inflated by peak integration errors.
• Check Counterion Type: TFA counterion is standard but may interfere with cell-based assays or formulation stability. Acetate counterion is preferred for cosmetic applications to avoid cytotoxicity and pH shifts.
• Assess Endotoxin Levels: For sterile manufacturing, require endotoxin testing per USP <85>. Research-grade peptide may tolerate higher levels, but always confirm the limit matches your application.
• Evaluate Storage Conditions: Ensure the supplier provides lyophilized powder in vacuum-sealed containers with desiccant. Request accelerated stability data to confirm shelf life claims.
• Review Regulatory Documentation: For international shipping, confirm the supplier provides a Certificate of Origin, Material Safety Data Sheet (MSDS), and any required customs declarations (e.g., HS code 2934.99 for peptide products).

Common pitfalls include accepting "research-grade" peptide for cosmetic formulation without endotoxin testing, or assuming that a low price reflects equivalent quality. Always request a sample batch (1-5 g) for in-house testing before committing to large orders. Reputable suppliers will provide samples at cost or free for qualified buyers.

Core Product Advantages

High-purity AOD 9604 peptide offers distinct advantages for B2B buyers across lab sourcing and manufacturing certification. These benefits directly impact operational efficiency, product quality, and market competitiveness.

Purity and Bioactivity: With ≥98% purity by HPLC, each batch delivers consistent biological activity in lipid metabolism assays and cosmetic formulations. This reduces the risk of batch failures and ensures reproducible results in research and product development.

Stability and Shelf Life: Lyophilized powder stored at -20°C maintains ≥95% purity for up to 2 years, minimizing inventory turnover and waste. Accelerated stability testing confirms that the peptide remains intact under recommended storage conditions, even during shipping in insulated containers with ice packs.

Cost Performance: Bulk pricing for high-purity AOD 9604 peptide ranges from $50 to $150 per gram, depending on quantity and documentation level. Compared to low-grade alternatives, the higher purity reduces the required dosage by 20-30%, offsetting the initial cost premium. For wholesale orders of 100 g or more, suppliers often offer tiered discounts and free shipping.

Technical Support: Reputable suppliers provide access to formulation guides, stability data, and regulatory assistance. This includes help with INCI name registration for cosmetic ingredients, or documentation for research ethics committee approvals. Technical support teams can also advise on reconstitution protocols, buffer compatibility, and storage optimization.

Frequently Asked Questions

Q1: What is the minimum purity required for AOD 9604 peptide in cosmetic formulations?
For cosmetic applications, a minimum purity of 98% by HPLC is recommended to ensure consistent bioactivity and avoid skin irritation from impurities. Lower purity grades (e.g., 95%) may be acceptable for non-sterile products but require additional stability testing to confirm no degradation occurs during formulation. Always request a Certificate of Analysis (CoA) with endotoxin levels below 0.5 EU/mg for topical use.

Q2: How should AOD 9604 peptide be stored to maintain stability during bulk shipping?
Lyophilized AOD 9604 peptide should be shipped in vacuum-sealed, light-resistant containers with desiccant and temperature indicators. Use insulated packaging with dry ice or gel packs to maintain temperatures below -20°C during transit. Upon receipt, store the peptide at -20°C in a freezer with minimal temperature fluctuations. Avoid repeated freeze-thaw cycles by aliquoting the peptide into single-use vials before reconstitution.

Q3: What documentation is required for importing AOD 9604 peptide for research purposes?
For research imports, suppliers should provide a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and a Certificate of Origin. Depending on the destination country, additional documents may include a customs declaration with HS code 2934.99, a phytosanitary certificate (if required), and a letter of intent for research use only. Always verify local regulations regarding peptide importation, as some countries require prior approval from health or customs authorities.