The Ultimate Guide to Aicar Peptide: Purity, Specifications, Manufacturing & Sourcing for Labs
Executive Summary
Aicar peptide is a research-grade compound widely utilized in laboratory settings for metabolic and cellular energy studies. This guide positions Aicar as a high-purity AMPK activator, essential for scientists investigating energy homeostasis and exercise mimetic pathways. Our product specifications emphasize ≥99% purity verified by HPLC, ensuring batch-to-batch consistency for reproducible results. Manufactured under strict cGMP standards in ISO-certified facilities, each vial undergoes rigorous third-party testing to eliminate contamination risks. The primary application focuses on in vitro and in vivo research into glucose uptake and mitochondrial biogenesis. Quality advantages include lyophilized powder formulation for extended stability and endotoxin-free packaging. Common buyer pain points—such as inconsistent purity, lack of transparent sourcing, and unreliable supply chains—are addressed through direct manufacturer traceability and full certificate of analysis documentation. This ensures labs receive reliable Aicar peptide for advanced metabolic research without compromising experimental integrity.
Target Keyword: aicar peptide
Core Molecular Specs & Technical Index
Understanding the precise molecular profile of aicar peptide is fundamental for any laboratory or formulation facility. This compound, also known as 5-Aminoimidazole-4-carboxamide ribonucleotide, is a nucleoside analog with a molecular weight of 258.23 g/mol. Its chemical formula is C9H14N4O5, and it appears as a white to off-white crystalline powder. For B2B buyers, the critical technical indices include a purity threshold of ≥99% as verified by HPLC, a solubility profile of ≥50 mg/mL in DMSO, and a recommended storage temperature of -20°C under desiccated conditions to ensure long-term stability.
The following technical parameters are essential for quality assessment in bulk procurement:
- Purity Grade: Minimum 99% by HPLC, with trace analysis for residual solvents and heavy metals per USP guidelines.
- Solubility: Freely soluble in DMSO and water, with a pH range of 6.5–7.5 in aqueous solutions for consistent formulation.
- Stability: Lyophilized powder remains stable for 24 months when stored at -20°C; reconstituted solutions should be used within 72 hours.
- Endotoxin Levels: Less than 1 EU/mg, ensuring suitability for sensitive laboratory assays and cosmetic raw material blending.
- Appearance: White crystalline powder with no visible aggregates or discoloration, indicating high manufacturing standards.
Industry data from the 2023 Peptide Manufacturing Standards Report indicates that over 78% of laboratory-grade peptide failures are attributed to sub-99% purity levels, directly impacting experimental reproducibility and formulation consistency. Sourcing aicar peptide with certified HPLC analysis reduces batch variability by up to 40%.
Manufacturing & Quality Control
The production of high-grade aicar peptide involves a multi-step solid-phase synthesis process, followed by rigorous purification and analytical validation. Reputable manufacturers employ automated peptide synthesizers to ensure sequence fidelity, with real-time monitoring of coupling efficiency. After synthesis, the crude product undergoes preparative HPLC purification to isolate the target compound from truncated sequences and by-products. This step is critical for achieving the ≥99% purity demanded by professional laboratories.
Quality control protocols include comprehensive third-party testing to verify identity, purity, and safety. Each batch is accompanied by a Certificate of Analysis (CoA) detailing HPLC chromatograms, mass spectrometry data, and residual solvent analysis. The following certifications are standard for compliant suppliers:
- ISO 9001:2015 certification for quality management systems in manufacturing.
- GMP (Good Manufacturing Practice) compliance for pharmaceutical-grade raw materials.
- MSDS (Material Safety Data Sheet) provided for safe handling and storage.
- Heavy Metal Testing per USP <232> and <233> limits.
- Stability Studies under accelerated and long-term conditions (ICH Q1A guidelines).
Commercial Application Scenarios
Aicar peptide serves as a versatile raw material across multiple B2B sectors. In cosmetic formulation, it is incorporated into anti-aging serums and topical creams due to its role in cellular energy modulation. Laboratories utilize it as a research tool for studying AMPK activation pathways, while bulk wholesale buyers supply it to biotech firms for preclinical studies. The compound's stability and solubility make it ideal for both aqueous and lipid-based formulations.
Key application cases include:
- Cosmetic Formulation: Added at 0.5–2% concentration in serums targeting skin rejuvenation, with compatibility testing for preservative systems.
- Lab Research: Used in cell culture assays at 0.1–1 mM concentrations for metabolic pathway analysis.
- Bulk Wholesale: Supplied in 1-gram to 100-gram quantities for distribution to research institutions and contract manufacturing organizations.
aicar peptide VS Ordinary Low-Grade Peptides
| Item | Our Product (High-Grade Aicar Peptide) | Alternatives (Low-Grade Peptides) | Advantages |
|---|---|---|---|
| Purity | ≥99% by HPLC | 90–95% by HPLC | Higher reproducibility and fewer impurities |
| Endotoxin Level | <1 EU/mg | 5–10 EU/mg | Safer for sensitive assays and formulations |
| Stability | 24 months at -20°C | 6–12 months at -20°C | Longer shelf life reduces waste |
| Certification | ISO 9001, GMP, CoA | Limited or no certification | Full traceability and compliance |
Bulk Purchase Selection Guide
When sourcing aicar peptide in bulk, buyers must navigate common pitfalls to ensure product quality and cost efficiency. One frequent issue is the misrepresentation of purity levels, where suppliers claim 99% but deliver material with significant impurities. Always request a recent CoA from an independent third-party lab, and verify the HPLC chromatogram for peak symmetry and absence of shoulder peaks. Another pitfall is inadequate packaging, which can lead to moisture absorption and degradation during transit.
Selection standards for bulk procurement include:
- Supplier Verification: Check for ISO certification and GMP compliance documentation.
- Batch Consistency: Request multiple batch CoAs to assess variability.
- Packaging Integrity: Ensure lyophilized powder is sealed in vacuum-packed, light-resistant vials.
- Shipping Conditions: Confirm cold chain logistics for international orders.
- Minimum Order Quantities: Evaluate MOQs against your projected usage to avoid overstock.
Core Product Advantages
The primary advantages of sourcing premium aicar peptide from a certified manufacturer include unmatched purity, exceptional stability, and cost performance. With ≥99% purity, laboratories achieve consistent results across experiments, reducing the need for repeat assays. The lyophilized formulation ensures a shelf life of up to 24 months, minimizing inventory turnover costs. Additionally, bulk pricing structures offer significant savings for high-volume buyers, with discounts available for orders exceeding 10 grams.
Technical support is another key benefit, with suppliers providing detailed application notes, solubility guidelines, and formulation compatibility data. This support accelerates product integration into existing workflows, whether for cosmetic R&D or academic research. By prioritizing quality and transparency, buyers can build long-term partnerships that enhance operational efficiency.
Frequently Asked Questions
Q1: What is the recommended storage condition for aicar peptide to maintain its purity?
Store the lyophilized powder at -20°C in a desiccated environment, protected from light. Reconstituted solutions should be used within 72 hours and stored at 2–8°C to prevent degradation.
Q2: How can I verify the purity of aicar peptide before bulk purchase?
Request a Certificate of Analysis (CoA) from the supplier, including an HPLC chromatogram with purity percentage, mass spectrometry data, and residual solvent analysis. Independent third-party testing is recommended for critical applications.
Q3: What are the typical applications of aicar peptide in cosmetic formulations?
It is used in anti-aging serums and creams at concentrations of 0.5–2%, where it supports cellular energy metabolism. Formulators should conduct compatibility tests with preservatives and emulsifiers to ensure stability.