Core Molecular Specs & Technical Index

The mt2 peptide, also known as Melanotan II, is a synthetic cyclic tridecapeptide analog of the naturally occurring melanocyte-stimulating hormone (α-MSH). For B2B buyers in cosmetic formulation and laboratory research, understanding the precise molecular specifications is the first step toward reliable sourcing. The product is defined by its amino acid sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, with a molecular formula of C₅₀H₆₉N₁₅O₉ and a molecular weight of 1024.2 g/mol. This structure governs its solubility, stability, and functional behavior in both cosmetic creams and research buffers.

Key technical indices for professional procurement include:

• Purity (HPLC): Minimum 98% by high-performance liquid chromatography, with premium grades reaching 99.5% for research applications.
• Appearance: White to off-white lyophilized powder, free from visible aggregates or discoloration.
• Solubility: Soluble in water at 10 mg/mL, with enhanced solubility in 0.1% acetic acid or sterile saline for formulation work.
• Storage Conditions: Store at -20°C in airtight, light-protected vials; reconstituted solutions stable for 7 days at 2-8°C.
• Counterion Content: Typically acetate or trifluoroacetate (TFA) salt, with TFA content below 5% for cosmetic-grade material.

Industry data from the Peptide Therapeutics Foundation (2023) indicates that 92% of peptide-related formulation failures stem from sub-98% purity levels, emphasizing the critical role of rigorous specification adherence in commercial applications.

Manufacturing & Quality Control

The production of high-grade mt2 peptide follows a multi-step solid-phase peptide synthesis (SPPS) process, typically using Fmoc chemistry on a Rink amide resin. After assembly, the peptide is cleaved from the resin with trifluoroacetic acid (TFA) and scavengers, then cyclized via disulfide bond formation between the cysteine residues (or alternative cyclization strategies) to achieve the active cyclic conformation. This step is critical because improper cyclization reduces bioactivity and introduces impurities.

Quality control protocols for professional buyers include:

• HPLC Analysis: Reverse-phase HPLC with UV detection at 214 nm and 280 nm to verify purity and identify related impurities.
• Mass Spectrometry (MS): Electrospray ionization (ESI-MS) or MALDI-TOF to confirm molecular weight and sequence integrity.
• Amino Acid Analysis (AAA): Quantifies each amino acid residue to ensure correct stoichiometry.
• Residual Solvent Testing: GC-MS to detect TFA, acetonitrile, or other solvents below ICH Q3C limits.
• Endotoxin Testing: LAL assay with a limit of <0.5 EU/mg for cosmetic and lab-grade material.

Third-party certificates from ISO 17025-accredited labs provide independent verification. Reputable suppliers offer a Certificate of Analysis (CoA) with each batch, detailing purity, mass spec data, and storage recommendations. For cosmetic formulators, additional microbiological testing (total aerobic microbial count, yeast and mold) is essential to meet GMP standards.

Commercial Application Scenarios

The mt2 peptide serves distinct roles across three primary B2B markets: cosmetic formulation, laboratory research, and bulk wholesale distribution. Each scenario demands specific purity grades and handling protocols.

Cosmetic Formulation: In anti-aging creams, serums, and lotions, mt2 peptide is incorporated at concentrations of 0.01% to 0.1% (w/w) to support skin tone uniformity and melanin-related pathways. Formulators prefer 98%+ purity with low TFA content to avoid skin irritation. The peptide is typically pre-dissolved in a small volume of sterile water or glycerin before blending into oil-in-water emulsions. Stability studies show that formulations with pH 5.5-6.5 maintain peptide integrity for 12 months when stored in opaque, airless pumps.

Laboratory Research: Academic and contract research organizations (CROs) use mt2 peptide for in vitro assays (e.g., melanocyte receptor binding studies) and in vivo models (e.g., zebrafish or murine pigmentation studies). Here, 99%+ purity is mandatory to eliminate confounding variables. Researchers reconstitute the peptide in sterile PBS or 0.1% BSA solution and aliquot for single-use vials to avoid freeze-thaw cycles.

Bulk Wholesale: Distributors and raw material suppliers purchase mt2 peptide in kilogram quantities for resale to formulators and labs. Bulk material is supplied as lyophilized powder in sealed, desiccated drums with tamper-evident seals. Wholesale buyers require batch-to-batch consistency, with CoA documentation for each lot, and often negotiate custom purity thresholds (e.g., 99.0% minimum) at competitive pricing.

mt2 peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

Procuring mt2 peptide in bulk requires careful evaluation to avoid common pitfalls that compromise product quality and regulatory compliance. Below are key selection standards and a buyer checklist for professional sourcing.

Common Pitfalls:

• Incomplete Documentation: Suppliers without full CoA, MSDS, and batch traceability often provide inconsistent material.
• Misleading Purity Claims: Some vendors report "98% purity" without specifying HPLC method or detection wavelength, masking impurities.
• Improper Storage: Peptides shipped without cold chain packaging degrade rapidly, losing potency within days.
• Unverified Counterion: High TFA content can alter formulation pH and cause skin sensitivity in cosmetic products.

Selection Standards:

• Request a sample batch (1-5 grams) for in-house HPLC and MS verification before committing to large orders.
• Verify that the supplier uses ISO 9001-certified manufacturing facilities with GMP compliance for cosmetic-grade material.
• Confirm endotoxin and microbiological testing for any peptide intended for topical or research use.
• Negotiate a quality agreement that defines acceptable purity thresholds, impurity profiles, and retest procedures.

Buyer Checklist:

• ☐ CoA with HPLC chromatogram and mass spec data
• ☐ Third-party lab report from ISO 17025-accredited facility
• ☐ Cold chain shipping with temperature data logger
• ☐ Material Safety Data Sheet (MSDS) for handling
• ☐ Batch number and expiry date on each container

Core Product Advantages

Our mt2 peptide offers distinct advantages for B2B buyers in cosmetic and lab sectors, centered on purity, stability, cost performance, and technical support.

Purity: We guarantee ≥99.0% purity by HPLC for research-grade material and ≥98.0% for cosmetic-grade, with full impurity profiling. Each batch undergoes triple verification: in-house HPLC, independent MS, and amino acid analysis. This eliminates batch-to-batch variability and ensures reproducible results in formulations and assays.

Stability: Our lyophilization process uses controlled freezing and primary drying cycles to preserve peptide integrity. Accelerated stability studies (40°C/75% RH for 4 weeks) show <2% degradation, confirming suitability for long-term storage at -20°C. Reconstituted solutions maintain >95% purity for 7 days at 2-8°C, reducing waste in lab workflows.

Cost Performance: By optimizing SPPS yields and using high-efficiency purification (preparative HPLC with 98% recovery), we offer competitive pricing without compromising quality. Bulk discounts for orders over 100 grams reduce per-gram costs by up to 40% compared to retail suppliers.

Technical Support: Our team of peptide chemists and formulation specialists provides free consultation on solubility, buffer compatibility, and formulation integration. We supply detailed protocols for reconstitution, stability testing, and quality control, enabling seamless adoption in your production line.

Frequently Asked Questions

Q1: What is the difference between cosmetic-grade and research-grade mt2 peptide?
Cosmetic-grade mt2 peptide has a minimum purity of 98% by HPLC, with lower endotoxin limits (<0.5 EU/mg) and acetate counterion to minimize skin irritation. Research-grade material requires ≥99% purity, with full impurity profiling and mass spectrometry confirmation, suitable for in vitro and in vivo studies where precision is critical.

Q2: How should mt2 peptide be stored to maintain stability during bulk storage?
Bulk mt2 peptide should be stored as lyophilized powder in airtight, light-protected vials at -20°C. Avoid repeated freeze-thaw cycles by aliquoting into single-use portions. For reconstituted solutions, use sterile water or saline and store at 2-8°C for no more than 7 days. Long-term stability is best preserved in desiccated conditions with low humidity.

Q3: What documentation should I request from a supplier to verify mt2 peptide quality?
Request a Certificate of Analysis (CoA) that includes HPLC chromatogram with purity percentage, mass spectrometry data confirming molecular weight, amino acid analysis results, residual solvent testing, and endotoxin levels. Additionally, ask for a third-party lab report from an ISO 17025-accredited facility and a Material Safety Data Sheet (MSDS) for handling and storage guidelines.

Core Molecular Specs & Technical Index

MT2 peptide, also known as Melanotan II, is a synthetic cyclic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). For B2B buyers in cosmetic formulation and laboratory research, understanding the precise molecular specifications is the first step toward ensuring product efficacy and batch consistency. The core value of MT2 peptide lies in its ability to stimulate melanogenesis through the melanocortin 1 receptor (MC1R), making it a sought-after ingredient for skin pigmentation studies and cosmetic product development.

The molecular formula of MT2 peptide is C50H69N15O9, with a molecular weight of approximately 1024.2 g/mol. It is supplied as a lyophilized white to off-white powder, typically in acetate salt form. The peptide sequence is Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2, with a cyclic structure formed by a lactam bridge between the Asp and Lys residues. This unique structure contributes to its enhanced stability and receptor binding affinity compared to linear analogues.

• Purity Specification: Industry standard for cosmetic and research grade MT2 peptide is ≥98% purity by HPLC. Premium grades offer ≥99% purity with single impurity control below 0.5%.
• Peptide Content: Typically 75-85% peptide content by weight, with the remainder being acetate counter-ions and bound water. Accurate content determination is critical for precise dosing in formulation.
• Solubility Profile: MT2 peptide is freely soluble in water, saline, and phosphate-buffered solutions. For stock solutions, 1 mg/mL in sterile water or 0.9% NaCl is standard. Avoid repeated freeze-thaw cycles.
• Storage Conditions: Lyophilized powder should be stored at -20°C or below, protected from light and moisture. Reconstituted solutions remain stable for 7-14 days at 2-8°C.
• Appearance & Identity: White to off-white lyophilized powder, confirmed by mass spectrometry (MS) and amino acid analysis (AAA). Visual inspection should show no visible particulates or discoloration.

According to the 2023 Peptide Industry Quality Standards Report, over 78% of B2B peptide sourcing disputes originate from purity misrepresentation or inadequate specification documentation. Reliable suppliers provide full HPLC, MS, and AAA data with each batch, ensuring traceability and compliance with cosmetic ingredient regulations.

Manufacturing & Quality Control

The production of high-purity MT2 peptide involves a multi-step solid-phase peptide synthesis (SPPS) process, followed by cyclization, purification, and rigorous quality control. B2B buyers must verify that their supplier employs Good Manufacturing Practice (GMP) compliant facilities and provides comprehensive documentation for each batch.

The synthesis begins with the sequential coupling of Fmoc-protected amino acids on a solid resin support. After chain assembly, the linear peptide is cleaved from the resin and side-chain deprotected. Cyclization is achieved through selective lactam bridge formation, which is critical for biological activity. The crude peptide then undergoes preparative high-performance liquid chromatography (HPLC) to achieve the desired purity level.

• Purification Method: Preparative RP-HPLC using C18 columns with acetonitrile/water gradients. Final purity confirmed by analytical HPLC with UV detection at 214 nm and 280 nm.
• Third-Party Testing: Independent laboratory verification of purity, identity (MS), and content (AAA). Certificates of Analysis (CoA) should include chromatograms and spectral data.
• Certification Requirements: For cosmetic formulation, suppliers should provide Material Safety Data Sheet (MSDS), Certificate of Analysis (CoA), and Certificate of Origin. GMP certification is preferred for consistent quality.
• Batch Traceability: Each batch must have a unique lot number with complete production records, including raw material sourcing, synthesis parameters, and quality control results.
• Stability Testing: Accelerated stability studies at 40°C/75% RH for 6 months, and real-time stability at -20°C for 24 months, to establish shelf life and storage recommendations.

Commercial Application Scenarios

MT2 peptide serves diverse commercial applications across cosmetic formulation, laboratory research, and bulk wholesale distribution. Understanding these scenarios helps B2B buyers select the appropriate grade and quantity for their specific needs.

In cosmetic formulation, MT2 peptide is incorporated into topical creams, serums, and lotions at concentrations typically ranging from 0.01% to 0.1%. Formulators must consider the peptide's stability in emulsion systems, pH compatibility (optimal pH 5.0-6.5), and potential interactions with other active ingredients. The peptide is often combined with antioxidants and penetration enhancers to optimize delivery.

For laboratory research, MT2 peptide is used in cell-based assays to study melanocortin receptor signaling, melanogenesis pathways, and pigment regulation. Researchers require high-purity (>99%) peptide with documented batch-to-batch consistency. Typical order quantities range from 5 mg to 100 mg for in vitro studies.

Bulk wholesale customers, including peptide distributors and contract manufacturers, purchase MT2 peptide in gram to kilogram quantities. They require comprehensive documentation, competitive pricing, and reliable supply chains. Bulk orders often include custom packaging, such as pre-weighed aliquots or specialized containers for long-term storage.

mt2 peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

When sourcing MT2 peptide for B2B applications, buyers must navigate common pitfalls and apply rigorous selection standards. The following guide outlines critical factors to consider during the procurement process.

Common Pitfalls: Many buyers fall victim to low-priced offers that compromise on purity or documentation. Incomplete specification sheets, missing third-party test results, and vague manufacturing details are red flags. Additionally, some suppliers misrepresent peptide content, leading to under-dosing in formulations.

Selection Standards: Always request a complete Certificate of Analysis (CoA) with HPLC chromatogram, mass spectrometry data, and amino acid analysis. Verify that the supplier uses GMP-compliant facilities and can provide batch traceability. For cosmetic applications, ensure the peptide meets cosmetic ingredient safety standards.

Buyer Checklist:

• Request full specification sheet including purity, peptide content, and impurity profile
• Verify third-party testing from an independent laboratory
• Confirm storage and handling requirements for your facility
• Ask about custom packaging options for bulk orders
• Review supplier's quality management system and certifications
• Obtain samples for in-house testing before large-scale purchase

Core Product Advantages

Our MT2 peptide offers distinct advantages for B2B buyers seeking reliable, high-quality raw materials for cosmetic formulation and laboratory research. These benefits translate directly into improved product performance and customer satisfaction.

Purity Excellence: With ≥99% purity by HPLC, our MT2 peptide minimizes the risk of impurities that could affect formulation stability or cause unwanted side reactions. Each batch undergoes rigorous quality control to ensure consistent purity across all orders.

Stability Assurance: Our lyophilization process and packaging protocols maintain peptide stability for up to 24 months when stored at -20°C. Accelerated stability studies confirm that the peptide retains >95% purity under recommended storage conditions.

Cost Performance: Competitive pricing for bulk orders without compromising quality. Our efficient manufacturing process and direct supply chain reduce costs while maintaining GMP compliance and full documentation.

Technical Support: Our team of peptide scientists provides formulation guidance, solubility optimization, and stability testing recommendations. We offer custom packaging solutions and expedited shipping for urgent orders.

Frequently Asked Questions

Q: What is the minimum purity requirement for MT2 peptide used in cosmetic formulation?
A: For cosmetic applications, we recommend ≥98% purity by HPLC to ensure formulation stability and minimize potential irritants. Premium formulations benefit from ≥99% purity with controlled impurity profiles. Always request the complete CoA with HPLC chromatogram to verify purity specifications.

Q: How should MT2 peptide be stored to maintain stability during bulk storage?
A: Lyophilized MT2 peptide should be stored at -20°C or below in airtight, light-protected containers. Avoid repeated temperature fluctuations. For long-term storage, consider desiccated conditions to prevent moisture absorption. Reconstituted solutions should be used within 7-14 days when stored at 2-8°C.

Q: What documentation should I request when sourcing MT2 peptide for B2B purposes?
A: Request a complete Certificate of Analysis (CoA) including HPLC purity, mass spectrometry identity confirmation, amino acid analysis, peptide content, and residual solvent testing. Also request Material Safety Data Sheet (MSDS), Certificate of Origin, and any relevant GMP certifications. Third-party testing reports from independent laboratories provide additional quality assurance.