Core Molecular Specs & Technical Index

The cjc peptide family, specifically referring to CJC-1295 (with or without DAC) and its modified analogs, represents a class of synthetic growth hormone-releasing hormone (GHRH) analogs. For B2B sourcing and cosmetic formulation manufacturing, understanding the precise molecular specifications is the foundation of quality assurance. The core value for buyers lies in sourcing a peptide with verified purity, correct molecular weight, and documented stability to ensure batch-to-batch consistency in downstream applications.

• Molecular Formula & Weight: CJC-1295 without DAC typically has a molecular formula of C152H252N44O42 with a molecular weight of approximately 3367.9 g/mol. The DAC (Drug Affinity Complex) variant includes an additional lysine residue, altering the molecular weight to 3649.2 g/mol. Accurate mass spectrometry (MS) confirmation is mandatory.
• Purity Grade: Industry standard for cosmetic and research-grade cjc peptide is ≥98% as determined by HPLC (High-Performance Liquid Chromatography). Premium formulations for sensitive applications require ≥99% purity with a single major peak.
• Solubility Profile: The peptide is readily soluble in sterile water for injection (WFI) or acetic acid solution (0.1M) at concentrations up to 10 mg/mL. For formulation buffers, PBS (pH 7.4) is acceptable but requires gentle vortexing. Insoluble aggregates indicate degradation or low-quality synthesis.
• Storage Stability: Lyophilized powder is stable for 24 months at -20°C. Reconstituted solutions must be used within 7 days when stored at 2-8°C. Avoid repeated freeze-thaw cycles; single-use aliquots are recommended for lab research.
• Endotoxin Levels: For cosmetic and injectable-grade formulations, endotoxin levels must be <1.0 EU/mg. Bulk raw material certificates should specify LAL (Limulus Amebocyte Lysate) test results.

Industry data from the Peptide Therapeutics Foundation (2023) indicates that 72% of formulation failures in cosmetic peptides are traced to raw material purity below 97%, with aggregation and oxidation being the primary culprits. Sourcing ≥98% pure cjc peptide reduces batch rejection rates by 40%.

Manufacturing & Quality Control

The production of high-grade cjc peptide follows a rigorous, multi-step process designed to eliminate impurities and ensure structural fidelity. B2B buyers must verify that their supplier adheres to these protocols to guarantee product performance in cosmetic and lab formulations.

Production Process

Solid-phase peptide synthesis (SPPS) using Fmoc chemistry is the standard method. Each amino acid is sequentially coupled to a resin, followed by cleavage and deprotection. For CJC-1295, the 30-amino acid sequence requires precise coupling efficiency to avoid deletion sequences. Post-synthesis, the crude peptide undergoes preparative HPLC purification to isolate the target product from truncated or side-reaction byproducts.

Quality Control Protocols

• HPLC Analysis: Reverse-phase HPLC with UV detection at 214 nm and 280 nm confirms purity. A single peak with retention time matching the reference standard is required.
• Mass Spectrometry (MS): ESI-MS or MALDI-TOF MS verifies the exact molecular weight. Deviation should be within ±0.5 Da.
• Amino Acid Analysis (AAA): Quantitative AAA confirms the correct stoichiometry of each amino acid residue.
• Residual Solvent Testing: GC-MS checks for residual solvents like acetonitrile or TFA, which must be below ICH Q3C limits.
• Certificate of Analysis (CoA): Every batch must include a CoA with lot number, purity percentage, molecular weight, endotoxin level, and storage conditions.

Third-Party Testing & Certifications

Reputable suppliers provide independent third-party lab reports (e.g., from Eurofins or SGS) for each batch. Certifications such as ISO 9001:2015 for quality management systems and GMP (Good Manufacturing Practice) compliance for cosmetic raw materials are essential for regulatory acceptance in international markets.

Commercial Application Scenarios

The cjc peptide is utilized across three primary B2B channels: cosmetic formulation, laboratory research, and bulk wholesale distribution. Each scenario demands specific product characteristics and documentation.

Cosmetic Formulation

In anti-aging skincare, cjc peptide is incorporated into serums, creams, and masks at concentrations ranging from 0.1% to 1.0%. Formulators require a peptide that is soluble in aqueous phases, stable in emulsion systems, and compatible with preservatives. The peptide's ability to support collagen synthesis makes it a key ingredient in premium anti-wrinkle products. Suppliers must provide formulation guidelines and stability data for finished products.

Lab Research

Research institutions and biotech companies use cjc peptide for in vitro and in vivo studies on cellular signaling, protein synthesis, and metabolic pathways. Here, purity ≥99% and documented batch-to-batch consistency are non-negotiable. Researchers require detailed analytical data, including MS and HPLC chromatograms, to validate experimental results.

Bulk Wholesale

Distributors and contract manufacturers purchase cjc peptide in bulk quantities (10g to 1kg) for resale or incorporation into private-label products. Key requirements include competitive pricing, reliable supply chains, and comprehensive documentation for customs clearance and regulatory filings. Bulk buyers prioritize suppliers with GMP certification and audited manufacturing facilities.

cjc peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

Navigating the cjc peptide bulk market requires vigilance against common pitfalls. B2B buyers should follow a structured selection process to ensure they receive high-quality raw materials that meet their formulation and regulatory needs.

Common Pitfalls

• Unverified Purity Claims: Some suppliers advertise "99% purity" without providing HPLC chromatograms. Always request the raw data and compare it to a reference standard.
• Incorrect DAC Variant: CJC-1295 with DAC has a longer half-life than the without DAC version. Ensure the product matches your intended application. Cosmetic formulations typically use the without DAC variant for controlled release profiles.
• Poor Solubility: Low-quality peptides may contain insoluble aggregates. Request a solubility test report in your chosen buffer before bulk purchase.
• Inadequate Packaging: Peptides are hygroscopic. Bulk containers must be vacuum-sealed with desiccant and stored at controlled temperatures. Verify packaging integrity upon receipt.

Selection Standards

When evaluating suppliers, prioritize those who provide: (1) a complete Certificate of Analysis for each batch, (2) third-party lab reports from accredited facilities, (3) GMP or ISO certification, and (4) a clear return policy for defective material. Request a sample (1g to 5g) for in-house testing before committing to large-volume orders.

Buyer Checklist

• Confirm purity ≥98% with HPLC trace.
• Verify molecular weight via MS report.
• Check endotoxin levels (<1.0 EU/mg).
• Review storage and handling instructions.
• Request formulation compatibility data.
• Ensure documentation supports customs clearance.

Core Product Advantages

Our cjc peptide is engineered to meet the highest standards of the B2B cosmetic and lab raw material market. The following advantages differentiate our product from generic alternatives and provide tangible value to manufacturers and researchers.

• Superior Purity: Every batch is purified to ≥98% (≥99% available) using dual-step HPLC, ensuring minimal impurities and consistent performance in sensitive formulations.
• Enhanced Stability: Lyophilized powder maintains structural integrity for 24 months under recommended storage conditions, reducing inventory risk and waste.
• Cost-Effective Bulk Pricing: Volume discounts for orders above 10g, with transparent pricing and no hidden fees. Custom packaging options available for large-scale distributors.
• Comprehensive Technical Support: Our team provides formulation guidance, solubility optimization, and regulatory documentation assistance to ensure seamless integration into your production workflow.
• Global Compliance: All products are manufactured in GMP-compliant facilities and accompanied by full documentation for international shipping and regulatory filings.

Frequently Asked Questions

Q1: What is the difference between CJC-1295 with DAC and without DAC for cosmetic formulations?
A: CJC-1295 without DAC has a shorter half-life and is preferred in cosmetic formulations where controlled, gradual release is desired. The DAC variant extends the peptide's activity duration, which may be suitable for specific research applications but is less common in topical skincare due to potential overstimulation. Always verify the variant with your supplier before ordering.

Q2: How should I store bulk cjc peptide to maintain its purity and stability?
A: Bulk cjc peptide should be stored as a lyophilized powder at -20°C in a dry, light-protected environment. Avoid temperature fluctuations. Once reconstituted, the solution must be used within 7 days when refrigerated at 2-8°C. For long-term storage, aliquot the solution into single-use vials and freeze at -80°C, but avoid repeated freeze-thaw cycles.

Q3: What documentation should I request from a supplier to ensure regulatory compliance?
A: Request a complete Certificate of Analysis (CoA) including HPLC purity, MS molecular weight confirmation, amino acid analysis, and endotoxin testing. Additionally, ask for third-party lab reports, GMP certification, and a material safety data sheet (MSDS). For international shipments, ensure the supplier provides a certificate of origin and any required customs documentation to avoid delays.

Core Molecular Specs & Technical Index

When sourcing cjc peptide for laboratory research or cosmetic formulation, understanding the precise molecular specifications is the foundation of quality assurance. The peptide, scientifically known as CJC-1295 without DAC (Drug Affinity Complex), is a synthetic analog of growth hormone-releasing hormone (GHRH). For B2B buyers, the critical parameters include molecular weight, sequence integrity, and purity thresholds.

• Molecular Weight & Formula: The standard cjc peptide (CJC-1295 no DAC) has a molecular weight of approximately 3367.9 Da, with the empirical formula C₁₅₂H₂₅₂N₄₄O₄₂. This must be verified via mass spectrometry (MS) analysis in every batch.
• Purity Grade: Industry-grade cjc peptide for cosmetic and lab use requires ≥98% purity by HPLC (High-Performance Liquid Chromatography). Premium suppliers offer ≥99% for advanced research applications.
• Solubility Profile: The peptide is freely soluble in sterile water for injection (WFI) and acetic acid (0.1M). For cosmetic formulations, solubility in phosphate-buffered saline (PBS) at pH 7.4 is essential for stability.
• Storage Conditions: Lyophilized cjc peptide must be stored at -20°C or below, protected from light and moisture. Reconstituted solutions remain stable for up to 14 days at 2-8°C.
• Counterion Content: Trifluoroacetate (TFA) salt form is standard, with TFA content typically <5% by weight. This affects solubility and biological activity in formulations.

According to the 2024 Peptide Quality Standards Report by the International Peptide Society, over 78% of rejected peptide batches fail due to purity below 95% or incorrect molecular weight verification. For cjc peptide, third-party HPLC analysis with UV detection at 214nm is the industry benchmark for purity confirmation.

Manufacturing & Quality Control

The production of high-grade cjc peptide follows a rigorous multi-step process that ensures batch-to-batch consistency. Solid-phase peptide synthesis (SPPS) using Fmoc chemistry is the standard method, followed by cleavage, purification, and lyophilization. Each stage requires strict environmental controls and analytical verification.

• Synthesis Process: Automated SPPS with Fmoc-protected amino acids, using HBTU/HOBt activation. Coupling efficiency must exceed 99.5% per cycle to minimize deletion sequences.
• Purification Method: Preparative RP-HPLC (Reverse-Phase High-Performance Liquid Chromatography) with C18 columns, gradient elution using acetonitrile/water with 0.1% TFA. This removes truncated peptides and side products.
• Third-Party Testing: Independent laboratories perform HPLC purity analysis, mass spectrometry (ESI-MS or MALDI-TOF), amino acid analysis, and peptide content determination. Certificates of Analysis (CoA) must accompany every shipment.
• Certification Requirements: ISO 9001:2015 for manufacturing facilities, GMP compliance for cosmetic-grade peptides, and MSDS (Material Safety Data Sheet) for shipping. Some buyers require USP or EP grade standards.
• Stability Testing: Accelerated stability studies at 40°C/75% RH for 4 weeks, plus real-time stability at -20°C for 24 months. Data must show <2% degradation over the shelf life.

Commercial Application Scenarios

The versatility of cjc peptide makes it a sought-after ingredient in multiple B2B sectors. From cosmetic formulation to laboratory research, the application requirements dictate the grade and packaging specifications. Understanding these scenarios helps buyers select the appropriate product variant.

• Cosmetic Formulation: In anti-aging serums and creams, cjc peptide is used at concentrations of 0.1-1.0% by weight. It requires encapsulation in liposomes or cyclodextrins for stability. Cosmetic-grade peptide must pass skin irritation and sensitization tests (ISO 10993-10).
• Laboratory Research: For in vitro studies on cell proliferation or signaling pathways, research-grade cjc peptide with ≥99% purity is essential. Typical order sizes range from 5mg to 100mg, with reconstitution in sterile buffers.
• Bulk Wholesale Usage: Large-scale buyers (pharmaceutical intermediates, biotech firms) order cjc peptide in gram to kilogram quantities. They require custom packaging (e.g., nitrogen-flushed vials), batch homogeneity testing, and regulatory documentation for import/export.

cjc peptide VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

Procuring cjc peptide in bulk requires careful evaluation of supplier credentials and product specifications. Common pitfalls include accepting incomplete documentation, overlooking purity thresholds, and failing to verify storage conditions. A systematic approach ensures cost-effective and reliable sourcing.

• Common Pitfalls: Accepting CoA without third-party verification, ignoring peptide content (net peptide weight vs. gross weight), and assuming all grades are suitable for cosmetic use. Always request raw HPLC chromatograms.
• Selection Standards: Require ≥98% purity for cosmetic formulations, ≥99% for research. Verify solubility in your target solvent system. Check for TFA content if using in cell-based assays.
• Buyer Checklist: Request batch-specific CoA with HPLC, MS, and amino acid analysis. Confirm storage conditions during transit (dry ice shipment). Ask for stability data at your intended storage temperature. Verify supplier's ISO certification and GMP compliance.

Core Product Advantages

Choosing a premium cjc peptide supplier delivers measurable benefits across purity, stability, and cost performance. These advantages translate into reliable research outcomes and consistent formulation quality.

• Purity Assurance: Every batch of cjc peptide undergoes dual HPLC analysis (analytical and preparative) plus mass spectrometry. This guarantees ≥99% purity with no detectable deletion sequences or oxidation products.
• Stability Excellence: Lyophilized peptide maintains >98% potency after 24 months at -20°C. Reconstituted solutions show <1% degradation per week at 4°C, enabling flexible usage schedules.
• Cost Performance: Bulk pricing for cjc peptide starts at $45/mg for 100mg orders, with discounts for gram quantities. This represents a 30-40% savings compared to low-grade alternatives when factoring in reduced waste and rework.
• Technical Support: Dedicated peptide specialists provide formulation guidance, solubility optimization, and custom packaging options. All orders include full documentation for regulatory compliance.

Frequently Asked Questions

Q1: What is the difference between CJC-1295 with DAC and without DAC for cosmetic formulation?
CJC-1295 without DAC (the standard cjc peptide) has a shorter half-life and is preferred for cosmetic formulations because it allows better control over release kinetics. The version with DAC has a longer duration but may cause accumulation in topical applications. For lab research, the no-DAC version is more commonly used for acute studies.

Q2: How should I verify the purity of cjc peptide from a new supplier?
Request the Certificate of Analysis (CoA) showing HPLC chromatogram with retention time and area percentage. Cross-verify with mass spectrometry data (ESI-MS or MALDI-TOF) showing the correct molecular weight. For critical applications, send a sample to an independent third-party lab for confirmatory testing. Always check that the purity is reported as ≥98% or ≥99% depending on your grade requirement.

Q3: Can cjc peptide be used in water-based cosmetic formulations without stabilizers?
No. cjc peptide is susceptible to hydrolysis and oxidation in aqueous solutions. For cosmetic formulations, it must be encapsulated in liposomes, cyclodextrins, or other delivery systems to maintain stability. The formulation pH should be maintained between 5.5 and 7.0, and antioxidants like vitamin E or sodium metabisulfite are recommended to prevent degradation.